OTX1 anticorps (AA 1-100) (AbBy Fluor® 488)

N° du produit ABIN1392208

Cet anticorps Lapin Polyclonal détecte spécifiquement OTX1 dans IF (cc) et IF (p). Il présente une réactivité envers Humain.

Aperçu rapide pour OTX1 anticorps (AA 1-100) (AbBy Fluor® 488) (ABIN1392208)

Antigène: OTX1 (Orthodenticle Homeobox 1 (OTX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTX1 est conjugé à/à la AbBy Fluor® 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-OTX1 anticorps (AbBy Fluor® 488)

Épitope: AA 1-100

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human OTX1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur OTX1

Antigène: OTX1 (Orthodenticle Homeobox 1 (OTX1))

Autre désignation: OTX1

Sujet:

Synonyms: Homeobox protein OTX 1, Homeobox protein OTX1, MGC15736, Orthodenticle 1, Orthodenticle homeobox 1, Orthodenticle homolog 1, Orthodenticle1, Otx 1, otx1, OTX1_HUMAN.

Background: Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p15 and 14q21-q22, respectively.