Elavl2 + Elavl4 (AA 31-110) anticorps (FITC)

N° du produit ABIN1393064

L’anticorps anti-Elavl2 + Elavl4 Polyclonal Lapin est utilisé pour la détection de Elavl2 + Elavl4 dans des échantillons de Rat. Il a été validé pour WB, IF (cc) et IF (p).

Aperçu rapide pour Elavl2 + Elavl4 (AA 31-110) anticorps (FITC) (ABIN1393064)

Antigène: Elavl2 + Elavl4

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit

Épitope: AA 31-110

Réactivité croisée: Rat

Homologie: Human,Mouse,Dog,Cow,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ELAVL2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: Elavl2 + Elavl4

Sujet:

Synonyms: ELAV like protein, ELAVL4, hCG_2031550, A0A0R4J2E6_HUMAN, ELAVL2, A0A0A0MRX1_HUMAN

Background: The Elav-like genes encode for a family of RNA-binding proteins. Elav, a Drosophila protein and the first described member, is expressed immediately after neuroblastic differentiation into neurons and is necessary for neuronal differentiation and maintenance. Several mammalian Elav-like proteins, designated HuC, HuD and Hel-N1, are also expressed in postmitotic neurons. An additional mammalian homolog, HuR, which is also designated HuA, is ubiquitously expressed and is also overexpressed in a wide variety of tumors. Characteristically, these homologs all contain three RNA recognition motifs (RRM) and they specifically bind to AU-rich elements (ARE) in the 3'-untranslated region of mRNAs transcripts. ARE sites target mRNA for rapid degradation and thereby regulate the expression levels of genes involved in cell growth and differentiation. When Elav-like proteins associate with these ARE sites this degradation is inhibited, leading to an increased stability of the corresponding transcript. Elav proteins function within the nucleus, and they are shuttled between the nucleus and cytoplasm by a nuclear export signal, which is a regulatory feature of the Elav-like proteins as it limits their accessibility to ARE sites.

ID gène: 1996, 1993

UniProt: A0A0R4J2E6, A0A0A0MRX1