ATL1 anticorps (AA 201-300) (AbBy Fluor® 647)

N° du produit ABIN1393152

Cet anticorps anti-ATL1 est un anticorps Lapin Polyclonal détectant ATL1 dans WB, IF (cc) et IF (p). Adapté pour Souris et Rat.

Aperçu rapide pour ATL1 anticorps (AA 201-300) (AbBy Fluor® 647) (ABIN1393152)

Antigène: ATL1 (Atlastin GTPase 1 (ATL1))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATL1 est conjugé à/à la AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-ATL1 anticorps (AbBy Fluor® 647)

Épitope: AA 201-300

Réactivité croisée: Souris, Rat

Homologie: Human,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SPG3A/Atlastin

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ATL1

Antigène: ATL1 (Atlastin GTPase 1 (ATL1))

Autre désignation: SPG3A/Atlastin

Sujet:

Synonyms: AD FSP, atl1, ATLA1_HUMAN, Atlastin GTPase 1, Atlastin-1, Atlastin1, Brain specic GTP binding protein, Brain-specic GTP-binding protein, FSP1, GBP-3, GBP3, GTP-binding protein 3, Guanine nucleotide-binding protein 3, Guanylate binding protein 3, hGBP3, HSN1D, Spastic paraplegia 3 protein A, SPG 3A, SPG3, SPG3A.

Background: Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10 % of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40 %.