ATL1 anticorps (AA 201-300) (Biotin)

N° du produit ABIN1393153

Détail du produit anti-ATL1 anticorps (Biotin)

Antigène: ATL1 (Atlastin GTPase 1 (ATL1))

Épitope: AA 201-300

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATL1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Souris, Rat

Homologie: Human,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SPG3A/Atlastin

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ATL1

Antigène: ATL1 (Atlastin GTPase 1 (ATL1))

Autre désignation: SPG3A/Atlastin (ATL1 Produits)

Synonymes: anticorps ATL1, anticorps SPG3A, anticorps fj46c01, anticorps wu:fj46c01, anticorps spg3a, anticorps MGC146251, anticorps AD-FSP, anticorps FSP1, anticorps GBP3, anticorps HSN1D, anticorps SPG3, anticorps atlastin1, anticorps 4930435M24Rik, anticorps Adfsp, anticorps Fsp1, anticorps Spg3, anticorps Spg3a, anticorps atlastin, anticorps Atlastin-1, anticorps atlastin GTPase 1, anticorps ATL1, anticorps atl1, anticorps Atl1

Sujet:

Synonyms: AD FSP, atl1, ATLA1_HUMAN, Atlastin GTPase 1, Atlastin-1, Atlastin1, Brain specic GTP binding protein, Brain-specic GTP-binding protein, FSP1, GBP-3, GBP3, GTP-binding protein 3, Guanine nucleotide-binding protein 3, Guanylate binding protein 3, hGBP3, HSN1D, Spastic paraplegia 3 protein A, SPG 3A, SPG3, SPG3A.

Background: Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10 % of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40 %.