TTBK2 anticorps (AA 1151-1244) (AbBy Fluor® 647)

N° du produit ABIN1393224

Cet anticorps anti-TTBK2 est un anticorps Lapin Polyclonal détectant TTBK2 dans WB, IF (cc) et IF (p). Adapté pour Humain.

Aperçu rapide pour TTBK2 anticorps (AA 1151-1244) (AbBy Fluor® 647) (ABIN1393224)

Antigène: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TTBK2 est conjugé à/à la AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-TTBK2 anticorps (AbBy Fluor® 647)

Épitope: AA 1151-1244

Homologie: Human,Mouse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TTBK2/SCA11

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur TTBK2

Antigène: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Autre désignation: TTBK2/SCA11

Sujet:

Synonyms: TTBK2/SCA11 Tau tubulin kinase 2, Spinocerebellar ataxia 11, Tau tubulin kinase 2, Tau-tubulin kinase 2, TTBK, TTBK 2, TTBK1, TTBK2 , TTBK2_HUMAN, TTK, KIAA0847, mKIAA0847, SCA11.

Background: SCA11 is a 1,244 amino acid protein that belongs to the protein kinase superfamily and the CK1 Ser/Thr protein kinase family. The SCA11 gene, comprising of 16 exons, produces a 5.6-kb transcript in which the longest open reading frame is 3,732 nucleotides. Defects in the SCA11 protein are the cause of the disorder spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. The SCA11 disorder is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. The SCA11 protein has also been implicated in Alzheimer disease and in tangle formation. Existing as three alternatively spliced isoforms, the SCA11 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 15q15.2.