MAP1LC3A/B anticorps (AA 25-121) (Biotin)

N° du produit ABIN1396212

Cet anticorps anti-MAP1LC3A/B est un anticorps Lapin Polyclonal détectant MAP1LC3A/B dans IHC (p) et ELISA. Adapté pour Humain et Rat.

Aperçu rapide pour MAP1LC3A/B anticorps (AA 25-121) (Biotin) (ABIN1396212)

Antigène: MAP1LC3A/B (MAP1LC3A,B)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP1LC3A/B est conjugé à/à la Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA

Détail du produit anti-MAP1LC3A/B anticorps (Biotin)

Épitope: AA 25-121

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MAP LC3 Alpha

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MAP1LC3A/B

Antigène: MAP1LC3A/B (MAP1LC3A,B)

Autre désignation: MAP 1A/1B LC3 Alpha/Beta

Sujet:

Synonyms: Microtubule-associated proteins 1A/B light chain 3A, Microtubule-associated proteins 1A/B light chain 3B, Microtubule-associated proteins 1Beta light chain 3A, Microtubule-associated proteins 1Beta light chain 3A, MAP1B LC3 A, MAP LC3 Beta, MAP-LC3 Beta, MAP1 light chain 3-like protein 1.MAP1LC3B.MLP3A_HUMAN

Background: Microtubule-associated proteins (MAPs) regulate microtubule stability and play critical roles in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP-light chain 3 beta (MAP-LC3 Beta) and MAP-light chain 3 alpha (MAP-LC3 alpha) are subunits of both MAP1A and MAP1B. MAP-LC3M Beta, a homolog of Apg8p, is essential for autophagy and associated to the autophagosome membranes after processing. Two forms of LC3 Beta, the cytosolic LC3-I and the membrane-bound LC3-II, are produced post-translationally. LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3, followed by the conversion of a fraction of LC3-I into LC3-II. LC3 enhances fibronectin mRNA translation in ductus arteriosus cells through association with 60S ribosomes and binding to an AU-rich element in the 3? untranslated region of fibronectin mRNA. This facilitates sorting of fibronectin mRNA onto rough endoplasmic reticulum and translation. MAP LC3 Beta may also be involved in formation of autophagosomal vacuoles. It is expressed primarily in heart, testis, brain and skeletal muscle.

ID gène: 54901, 84557

UniProt: Q9H492, Q9GZQ8