MLC1 anticorps (AA 321-377) (Biotin)

N° du produit ABIN1397902

Cet anticorps Lapin Polyclonal détecte spécifiquement MLC1 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour MLC1 anticorps (AA 321-377) (Biotin) (ABIN1397902)

Antigène: MLC1

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLC1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-MLC1 anticorps (Biotin)

Épitope: AA 321-377

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MLC1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MLC1

Antigène: MLC1

Sujet:

Synonyms: KIAA0027, LVM, Megalencephalic leukoencephalopathy with subcortical cysts 1, Membrane protein MLC1, MLC, MLC-1, MLC1_HUMAN, VL, WKL1.

Background: MLC1 is a 377 amino acid multi-pass membrane protein that may serve as a non-selective neuronal cation channel in brain. Mutant MLC1 proteins that show impaired folding have been corrected in vitro with the addition of a Ca(2+)-ATPase inhibitor, curcumin. Mutations in the gene encoding MLC1 is the cause of megalencephalic leukoencephalopathy with subcortical cysts, also known as van der Knaap disease, a rare syndrome characterized early in life by progressive brain destruction causing mental retardation and incoordination. Single nucleotide polymorphisms within the MLC1 gene may be associated with periodic catatonia, but there seems to be conflicting evidence on whether or not the gene is implicated in general schizophrenia.

ID gène: 23209

UniProt: Q15049