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FBXW8 anticorps (AA 181-280) (Biotin)

FBXW8 Reactivité: Rat WB, ELISA, IHC (p), IHC (fro) Hôte: Lapin Polyclonal Biotin
N° du produit ABIN1398841
  • Antigène Voir toutes FBXW8 Anticorps
    FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))
    Épitope
    • 14
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    AA 181-280
    Reactivité
    • 21
    • 15
    • 9
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Rat
    Hôte
    • 34
    • 1
    Lapin
    Clonalité
    • 35
    Polyclonal
    Conjugué
    • 12
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FBXW8 est conjugé à/à la Biotin
    Application
    • 34
    • 16
    • 13
    • 13
    • 13
    • 12
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
     Réactivité croisée
    Rat
    Homologie
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human FBXW8/FBXO29
    Isotype
    IgG
    Top Product
    Discover our top product FBXW8 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C for 12 months.
    Date de péremption
    12 months
  • Antigène
    FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))
    Autre désignation
    FBXW8 (FBXW8 Produits)
    Synonymes
    anticorps FBW6, anticorps FBW8, anticorps FBX29, anticorps FBXO29, anticorps FBXW6, anticorps 4930438M06Rik, anticorps Fbx29, anticorps F-box and WD repeat domain containing 8, anticorps ring finger protein, transmembrane 2, anticorps F-box and WD-40 domain protein 8, anticorps FBXW8, anticorps Fbxw8, anticorps RNFT2
    Sujet

    Synonyms: F box/WD repeat containing protein 8; F box and WD40 domain containing protein 8; F-box only protein 29; F box only protein 29; FBW6; FBW8; FBX29; FBXO29; FBXW6; FBXW8_HUMAN.

    Background: FBXO29, also designated F-box/WD repeat-containing protein 8 (FBXW8), is a 598 amino acid protein that contains one 40 amino acid F-box region, making it a member of the F-box family. FBXO29 also contains five WD repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-å and -catenin, for degradation by the proteasome after ubiquitination. Functioning as a component of the SCF complex, FBXO29 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation. FBXO29 exists as two isoforms as a result of alternative splicing events.

    ID gène
    26259
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