SHARPIN anticorps (AA 260-310) (Biotin)

N° du produit ABIN1403515

Cet anticorps Lapin Polyclonal détecte spécifiquement SHARPIN dans WB et IHC (p). Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour SHARPIN anticorps (AA 260-310) (Biotin) (ABIN1403515)

Antigène: SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SHARPIN est conjugé à/à la Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SHARPIN anticorps (Biotin)

Épitope: AA 260-310

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SHARPIN

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SHARPIN

Antigène: SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))

Autre désignation: SHARPIN

Sujet:

Synonyms: SIPL1, Sharpin, Shank-associated RH domain-interacting protein, Shank-interacting protein-like 1, hSIPL1, PSEC0216

Background: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

ID gène: 81858

UniProt: Q9H0F6