ATRIP anticorps (pSer68, pSer72) (Cy7)

N° du produit ABIN1407900

Cet anticorps anti-ATRIP est un anticorps Lapin Polyclonal détectant ATRIP dans WB, IF (p) et IF (cc). Adapté pour Humain.

Aperçu rapide pour ATRIP anticorps (pSer68, pSer72) (Cy7) (ABIN1407900)

Antigène: ATRIP (ATR Interacting Protein (ATRIP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATRIP est conjugé à/à la Cy7

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Détail du produit anti-ATRIP anticorps (Cy7)

Épitope: pSer68, pSer72

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human ATRIP around the phosphorylation site of Ser68 + Ser72 [LA(p-S)QAL(p-S)QC]

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ATRIP

Antigène: ATRIP (ATR Interacting Protein (ATRIP))

Autre désignation: ATRIP+

Sujet:

Synonyms: ATRIP phospho S68 + S72, ATRIP Ser68 + Ser72, P-ATRIP Ser68/Ser72, AGS 1, AGS1, AGS-1, Aicardi Goutieres syndrome 1, ATIP, ATM and Rad3 related interacting protein, ATM and Rad3-related-interacting protein, ATR interacting protein, ATR-interacting protein, Atrip, ATRIP_HUMAN, Deoxyribonuclease III dnaQ/mutD E. coli like, DKFZp434J0310, DKFZp762J2115, DNase III, DRN 3, DRN3, FLJ12343, MGC20625, MGC26740, Three prime repair exonuclease 1, TREX 1, TREX1, TREX1 protein, MGC21482, 3' repair exonuclease 1, 3'-5' exonuclease TREX1.

Background: DNA damage or incomplete replication of DNA results in the inhibition of cell cycle progression at the G1 to S or the G2 to M phase transition by conserved regulatory mechanisms known as cell cycle checkpoints. Checkpoint proteins include Rad17, which is involved in regulating cell cycle progression at the G1 checkpoint as well as Chk1, Chk2, Rad1, Rad9 and Hus1, which are involved in regulating cell cycle arrest at the G2 checkpoint. In response to DNA damage, ATM and ATR kinases are important for cell cycle checkpoint response signalling. ATR-interacting protein (ATRIP), also designated ATM and Rad3-related-interacting protein, is required for checkpoint signaling after DNA damage. It is also important for ATR expression, which regulates DNA replication and damage checkpoint responses. ATRIP is a ubiquitously expressed protein that can form heterodimers with ATR. After dimerization they bind the RPA complex and are recruited to single stranded DNA. ATRIP is a nuclear protein that may also play a role in protein stabilization.