CREB3L3 anticorps (AA 201-300) (HRP)

N° du produit ABIN1407992

L’anticorps anti-CREB3L3 Polyclonal Lapin est utilisé pour la détection de CREB3L3 dans des échantillons de Humain. Il a été validé pour WB, ELISA, IHC (fro) et IHC (p).

Aperçu rapide pour CREB3L3 anticorps (AA 201-300) (HRP) (ABIN1407992)

Antigène: CREB3L3 (cAMP Responsive Element Binding Protein 3-Like 3 (CREB3L3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CREB3L3 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CREB3L3 anticorps (HRP)

Épitope: AA 201-300

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CREB-H

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur CREB3L3

Antigène: CREB3L3 (cAMP Responsive Element Binding Protein 3-Like 3 (CREB3L3))

Autre désignation: CREB-H/CREB3L3

Sujet:

Synonyms: cAMP responsive element binding protein 3 like 3, cAMP responsive element-binding protein 3 like protein 3, CREB H, CREB/ATF family transcription factor, CREBH, Cyclic AMP responsive element binding protein 3 like protein 3, cAMP-responsive element-binding protein 3-like protein 3, HYST1481, MGC126553, MGC126557, Transcription factor CREB H, CR3L3_HUMAN.

Background: CREB3L3 is a 461 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum (ER) and, in response to ER stress, is cleaved and translocated to the nucleus. Expressed exclusively in liver, CREB3L3 functions as a transcription factor that, during ER stress, is thought to activate genes that are involved in both the unfolded protein response and the acute phase response (APR). Additionally, CREB3L3 is underexpressed in hepatocellular carcinoma, suggesting a possible role as a tumor suppressor. CREB3L3 functions as a dimer and contains one leucine zipper domain, a KDEL-like sequence and a bZIP domain, through which it conveys its DNA binding ability. Three isoforms of CREB3L3 exist due to alternative splicing events.

Pathways: Thyroid Hormone Synthesis