THRB anticorps (AA 201-300) (Cy3)

N° du produit ABIN1409181

Détail du produit anti-THRB anticorps (Cy3)

Antigène: THRB (Thyroid Hormone Receptor, beta (THRB))

Épitope: AA 201-300

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THRB est conjugé à/à la Cy3

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Homologie: Cow,Sheep,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Thyroid Hormone Receptor beta

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur THRB

Antigène: THRB (Thyroid Hormone Receptor, beta (THRB))

Autre désignation: THRB (THRB Produits)

Synonymes: anticorps C-ERBA-2, anticorps C-ERBA-BETA, anticorps ERBA2, anticorps GRTH, anticorps NR1A2, anticorps PRTH, anticorps THR1, anticorps THRB1, anticorps THRB2, anticorps Nr1a2, anticorps T3R[b], anticorps T3Rbeta, anticorps Thrb1, anticorps Thrb2, anticorps c-erbAbeta, anticorps TR-beta, anticorps TR[b]1, anticorps fj24f03, anticorps trb, anticorps wu:fj24f03, anticorps CTR BETA 2, anticorps TR-BETA, anticorps LOC734147, anticorps thrb, anticorps THRB, anticorps C-erba-beta, anticorps RATT3REC, anticorps T3rec, anticorps TRbeta, anticorps THR, anticorps TRbeta1, anticorps thyroid hormone receptor beta, anticorps thyroid hormone receptor, beta, anticorps thyroid hormone receptor, beta S homeolog, anticorps thyroid hormone receptor, beta L homeolog, anticorps THRB, anticorps Thrb, anticorps thrb, anticorps thrb.S, anticorps thrb.L

Sujet:

Synonyms: Thyroid Hormone Receptor beta, Avian erythroblastic leukemia viral v erb a oncogene homolog 2, C ERBA 2, C ERBA BETA, c-erbA-2, c-erbA-beta, ERBA 2, ERBA BETA, ERBA2, Erythroblastic leukemia viral v erb a oncogene homolog 2 avian, generalized resistance to thyroid hormone, GRTH, MGC126109, MGC126110, NR1A2, Nuclear receptor subfamily 1 group A member 2, Oncogene ERBA2, PRTH, THB_HUMAN, THR 1, THR1, THRB 1,

Background: Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptor b2 (TRb2) is a high affinity receptor for triiodothyronine which belongs to the nuclear hormone receptor family and the NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Defects in the receptor result in generalized thyroid hormone resistance (GTHR). GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone.

ID gène: 7068

UniProt: P10828

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound