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RGMB anticorps (AA 58-160) (Cy7)

RGMB Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Cy7
N° du produit ABIN1409376
  • Antigène Voir toutes RGMB Anticorps
    RGMB (RGM Domain Family, Member B (RGMB))
    Épitope
    • 14
    • 8
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 58-160
    Reactivité
    • 37
    • 6
    • 2
    • 1
    Humain
    Hôte
    • 36
    • 1
    Lapin
    Clonalité
    • 37
    Polyclonal
    Conjugué
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RGMB est conjugé à/à la Cy7
    Application
    • 37
    • 13
    • 12
    • 12
    • 7
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Repulsive Guidance Molecule B
    Isotype
    IgG
    Top Product
    Discover our top product RGMB Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    RGMB (RGM Domain Family, Member B (RGMB))
    Autre désignation
    RGMB/Repulsive Guidance Molecule B (RGMB Produits)
    Synonymes
    anticorps dragon, anticorps DRAGON, anticorps 1110059F19Rik, anticorps repulsive guidance molecule family member b, anticorps repulsive guidance molecule family member B, anticorps rgmb, anticorps RGMB, anticorps Rgmb
    Sujet

    Synonyms: Dragon, DRG11-responsive axonal guidance and outgrowth of neurite, Repulsive Guidance Molecule B, RGM b, RGM domain family member B, Rgmb, RGMB_HUMAN.

    Background: The repulsive guidance molecule (RGM) family of proteins are important in the guidance of growth cones of developing neurons. They are repulsive for a group of axons, those from the temporal half of the retina. RGM have been implicated in both axonal guidance and neural tube closure but as opposed to for ephrins, semaphorins, netrins and slits, no receptor mechanism for RGM activation has been defined. Dorsal root ganglion axons do not respond to RGM but neogenin (a netrin-binding protein which can function as an RGM receptor) expression can spur RGM responsiveness. The RGM proteins are attached to the membrane by a GPI-anchor. Two members of this family, RGMa and RGMb, are expressed in the nervous system. RGMc, also known as Hemojuvelin, is a part of the signaling pathway activating hepcidin and works together with hepcidin to restrict iron absorption in the gut. Defects in the gene encoding for RGMc causes the autosomal recessive disorder juvenile hemochromatosis (JH).

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