FEZF1 anticorps (AA 199-280) (HRP)

N° du produit ABIN1409516

L’anticorps Lapin Polyclonal anti-FEZF1 a été validé pour ELISA, IHC (fro) et IHC (p). Il convient pour détecter FEZF1 dans des échantillons de Humain.

Aperçu rapide pour FEZF1 anticorps (AA 199-280) (HRP) (ABIN1409516)

Antigène: FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FEZF1 est conjugé à/à la HRP

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-FEZF1 anticorps (HRP)

Épitope: AA 199-280

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ZNF312B

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur FEZF1

Antigène: FEZF1 (FEZ Family Zinc Finger 1 (FEZF1))

Autre désignation: ZNF312B/FEZF1

Sujet:

Synonyms: FEZ, FEZ family zinc finger 1, Fez family zinc finger protein 1, fez like, fezf1, FEZF1_HUMAN, Zinc finger protein 312 like, Zinc finger protein 312B.

Background: Olfactory sensory neurons contain olfactory receptors, which are G protein-coupled receptor proteins that localize to the cilia and display affinity for and bind to a variety of odor molecules. Olfactory neurons send their axons from the olfactory epithelium to the olfactory bulb, which is covered by the CNS basal lamina. FEZF1 (Fez family zinc finger protein 1), also known as Forebrain Embryonic Zinc Finger and Zinc finger protein 312B, is a 475 amino acid nuclear protein that is expressed in the olfactory epithelium and hypothalamus of mice. In FEZF1-deficient mice, axons of olfactory neurons do not reach the olfactory bulb, suggesting that FEXF1 is required for the penetration of olfactory axons though the basal lamina before innervation of the olfactory bulb. When FEZF1 translocates to the nucleus, it induces KRAS overexpression, resulting in activation of ERK-signaling. Overexpression of FEZF1 leads to accelerated proliferation in cultured cells and increased tumor mass in mice. There are three isoforms of FEZF1 that are produced as a result of alternative splicing events.