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Humainin anticorps (AA 1-24) (Cy7)

MT-RNR2 Reactivité: Humain IF (cc), IF (p) Hôte: Lapin Polyclonal Cy7
N° du produit ABIN1410396
  • Antigène Tous les produits Humanin (MT-RNR2)
    Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))
    Épitope
    • 15
    • 3
    AA 1-24
    Reactivité
    • 22
    • 5
    • 3
    Humain
    Hôte
    • 27
    Lapin
    Clonalité
    • 27
    Polyclonal
    Conjugué
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Humanin est conjugé à/à la Cy7
    Application
    • 12
    • 12
    • 11
    • 5
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Humanin
    Isotype
    IgG
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C/-80 °C
    Stockage commentaire
    Store at -20°C, for long storage, store at -80°C. Avoid multiple freeze-thaw cycles
    Date de péremption
    12 months
  • Antigène
    Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))
    Autre désignation
    Humanin (MT-RNR2 Produits)
    Synonymes
    anticorps MTRNR2, anticorps l-rRNA, anticorps RNR2
    Sujet

    Humanin, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids. The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimer's disease genes. Humanin protects neuronal cells from damage caused by Alzheimer's disease genes, specifically APP (amyloid precursor protein). Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP. The peptide prevents Bax translocation from cytosol to mitochondria. Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities. The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO). Humanin is mainly expressed in the kidney, heart, liver, testis and skeletal muscles.

    Subcellular location: Secreted

    Synonyms: HN,HUNIN, HUNIN_HUMAN.

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