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Coagulation Factor VIII-Associated 1 (F8A1) (AA 2-80) anticorps (HRP)

F8A1 Reactivité: Humain WB, IHC (fro), IHC (p), ELISA Hôte: Lapin Polyclonal HRP
N° du produit ABIN1410692
  • Antigène Voir toutes Coagulation Factor VIII-Associated 1 (F8A1) Anticorps
    Coagulation Factor VIII-Associated 1 (F8A1)
    Épitope
    • 14
    • 1
    • 1
    • 1
    AA 2-80
    Reactivité
    • 18
    • 2
    • 1
    Humain
    Hôte
    • 19
    Lapin
    Clonalité
    • 19
    Polyclonal
    Conjugué
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    HRP
    Application
    • 19
    • 13
    • 13
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
    Homologie
    Human,Mouse,Rat,Cow
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human HAP40
    Isotype
    IgG
    Top Product
    Discover our top product F8A1 Anticorps primaire
  • Indications d'application
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Conseil sur la manipulation
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Coagulation Factor VIII-Associated 1 (F8A1)
    Autre désignation
    HAP40/F8a (F8A1 Produits)
    Synonymes
    anticorps DXS522E, anticorps F8A, anticorps HAP40, anticorps F8a, anticorps Hap40, anticorps RGD1566014, anticorps f8a, anticorps f8a1, anticorps hap40, anticorps dxs522e, anticorps MGC147036, anticorps coagulation factor VIII associated 1, anticorps coagulation factor VIII-associated 1, anticorps coagulation factor VIII, anticorps F8A1, anticorps F8a1, anticorps f8a1
    Sujet

    Synonyms: Coagulation factor 8 associated intronic transcript 1, Coagulation factor VIII associated intronic transcript 1, CpG island protein, DXS522E, F8a, F8A1, F8A2, F8A3, Factor 8 associated protein, Factor 8 intron 22 protein, Factor VIII associated protein, Factor VIII intron 22 protein, huntingtin associated protein 40, F8I2_HUMAN.

    Background: The Huntingtin protein contains a polyglutamine region, which leads to Huntingtin?s disease (HD) when the number of glutamine repeats exceeds thirty-five. The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), HAP40, Rab5 and HIP1. HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes. Specifically, this complex regulates endosome motility, which may be a key event of the pathogenetic process leading to neurodegeneration in HD.

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