GDAP1 anticorps (AA 151-230) (HRP)

N° du produit ABIN1410854

L’anticorps anti-GDAP1 Polyclonal Lapin est utilisé pour la détection de GDAP1 dans des échantillons de Humain. Il a été validé pour WB, IHC (fro) et IHC (p).

Aperçu rapide pour GDAP1 anticorps (AA 151-230) (HRP) (ABIN1410854)

Antigène: GDAP1 (Ganglioside-Induced Differentiation-Associated Protein 1 (GDAP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GDAP1 est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-GDAP1 anticorps (HRP)

Épitope: AA 151-230

Fonction: GDAP1 Polyclonal Antibody, HRP Conjugated

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit,Orangutan

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GDAP1

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000),

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GDAP1

Antigène: GDAP1 (Ganglioside-Induced Differentiation-Associated Protein 1 (GDAP1))

Autre désignation: GDAP1

Sujet:

Synonyms: Ganglioside induced dferentiation associated protein 1, Ganglioside-induced dferentiation-associated protein 1, GDAP1, GDAP1_HUMAN.

Background: Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although it shares the carboxy and amino-terminal glutathione S-transferase domains, GDAP1 is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, two characteristics which are unusual for GST family members. GDAP1 may function in a signal transduction pathway that is responsible for ganglioside-induced neurite differentiation and also may play a role in protecting myelin membranes from free-radical damage. Mutations in the gene encoding GDAP1 is the cause of many forms of Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system that is characterized by reduced nerve conduction velocities, slow progressive distal muscle atrophy and absent deep tendon reflexes.