Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

PRND anticorps (AA 51-120) (Cy7)

PRND Reactivité: Humain WB, IF (p), IF (cc) Hôte: Lapin Polyclonal Cy7
N° du produit ABIN1410894
  • Antigène Voir toutes PRND Anticorps
    PRND (Prion Protein 2 (Dublet) (PRND))
    Épitope
    • 14
    • 2
    AA 51-120
    Reactivité
    • 17
    • 3
    • 1
    Humain
    Hôte
    • 18
    Lapin
    Clonalité
    • 18
    Polyclonal
    Conjugué
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PRND est conjugé à/à la Cy7
    Application
    • 18
    • 12
    • 12
    • 6
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Homologie
    Human,Mouse,Rat,Cow,Pig
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Doppel
    Isotype
    IgG
    Top Product
    Discover our top product PRND Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    PRND (Prion Protein 2 (Dublet) (PRND))
    Autre désignation
    Doppel/DPL (PRND Produits)
    Synonymes
    anticorps PRND, anticorps DOPPEL, anticorps DPL, anticorps PrPLP, anticorps dJ1068H6.4, anticorps dpl, anticorps AI450264, anticorps Dpl, anticorps doppel, anticorps prion like protein doppel, anticorps PRND, anticorps Prnd
    Sujet

    Synonyms: DPL, Dublet, MGC41841, Prion gene complex downstream, Prion like protein doppel, Prion protein 2 dublet, Prion protein 2, Prion-like protein doppel, PRND, PRND_HUMAN, PrPLP.

    Background: Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, including scrapie in sheep, BSE in cattle, and Cruetzfeldt-Jacob disease in humans. The PRND gene locus, located on human chromosome 20p, encodes for the doppel protein (Dpl), which exhibits approximately 25 % sequence homology with PrP. Dpl is characterized by an alpha-helical conformation, intramolecular disulfide bonds, and two N-linked oligosaccharides, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor. Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice. Dpl does not appear to contribute to prion disease progression, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice. Dpl is also thought to play a role in angiogenesis, specifically maturation of the blood-brain barrier.

    Pathways
    Transition Metal Ion Homeostasis
Vous êtes ici:
Support technique