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MTMR2 anticorps (AA 371-450) (Cy7)

MTMR2 Reactivité: Humain WB, IF (cc), IF (p) Hôte: Lapin Polyclonal Cy7
N° du produit ABIN1410900
  • Antigène Voir toutes MTMR2 Anticorps
    MTMR2 (Myotubularin Related Protein 2 (MTMR2))
    Épitope
    • 14
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 371-450
    Reactivité
    • 25
    • 2
    • 1
    Humain
    Hôte
    • 24
    • 1
    Lapin
    Clonalité
    • 24
    • 1
    Polyclonal
    Conjugué
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MTMR2 est conjugé à/à la Cy7
    Application
    • 21
    • 12
    • 12
    • 9
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Cow,Sheep,Pig,Chicken,Rabbit,Zebrafish
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human MTMR2
    Isotype
    IgG
    Top Product
    Discover our top product MTMR2 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    MTMR2 (Myotubularin Related Protein 2 (MTMR2))
    Autre désignation
    MTMR2 (MTMR2 Produits)
    Synonymes
    anticorps MTMR2, anticorps DKFZp459I198, anticorps CMT4B, anticorps CMT4B1, anticorps 6030445P13Rik, anticorps zgc:153915, anticorps myotubularin related protein 2, anticorps MTMR2, anticorps Mtmr2, anticorps mtmr2
    Sujet

    Synonyms: CMT4B, CMT4B1, KIAA1073, MTMR2, MTMR2_HUMAN, Myotubularin related protein 2, Myotubularin-related protein 2.

    Background: Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterized by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.

    Pathways
    Inositol Metabolic Process, Synaptic Membrane
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