MTMR2 anticorps (AA 371-450) (HRP)

N° du produit ABIN1410902

L’anticorps Lapin Polyclonal anti-MTMR2 a été validé pour WB, ELISA, IHC (p) et IHC (fro). Il convient pour détecter MTMR2 dans des échantillons de Humain.

Aperçu rapide pour MTMR2 anticorps (AA 371-450) (HRP) (ABIN1410902)

Antigène: MTMR2 (Myotubularin Related Protein 2 (MTMR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTMR2 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-MTMR2 anticorps (HRP)

Épitope: AA 371-450

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Chicken,Rabbit,Zebrafish

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MTMR2

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur MTMR2

Antigène: MTMR2 (Myotubularin Related Protein 2 (MTMR2))

Autre désignation: MTMR2

Sujet:

Synonyms: CMT4B, CMT4B1, KIAA1073, MTMR2, MTMR2_HUMAN, Myotubularin related protein 2, Myotubularin-related protein 2.

Background: Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterized by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.

Pathways: Inositol Metabolic Process, Synaptic Membrane