DMPK anticorps (AA 51-120) (HRP)

N° du produit ABIN1410950

Détail du produit anti-DMPK anticorps (HRP)

Antigène: DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

Épitope: AA 51-120

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMPK est conjugé à/à la HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DMPK

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur DMPK

Antigène: DMPK (Dystrophia Myotonica-Protein Kinase (DMPK))

Autre désignation: DMPK (DMPK Produits)

Synonymes: anticorps DMPK, anticorps DM, anticorps DM1, anticorps DM1PK, anticorps DMK, anticorps MDPK, anticorps MT-PK, anticorps Dm15, anticorps DM1 protein kinase, anticorps dystrophia myotonica-protein kinase, anticorps DMPK, anticorps Dmpk

Sujet:

Synonyms: Dystrophia myotonica protein kinase, DM 1, DM, DM kinase, DM protein kinase, DM-kinase, DM1, DM1 protein kinase, DM1PK, DMK, DMPK, DMPK_HUMAN, Dystrophia myotonica 1, Dystrophia myotonica protein kinase, MDPK, MT PK, MT-PK, Myotonic dystrophy associated protein kinase, Myotonic dystrophy protein kinase, Myotonin protein kinase A, Myotonin protein kinase, Myotonin-protein kinase, Thymopoietin homolog.

Background: Myotonic dystrophy protein kinase is a multi-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis (1). DMPK is implicated in myotonic muscular dystrophy (DM), an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction (2,3). DM arises through expansion of CTG repeats in the 3?-UTR of the DMPK gene (4). Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus (5). These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP)/SIX5, to mediate in part the DM phenotype (6). Other substrates for DMPK include myogenin, L-type calcium channels, and Phospholemman (PLM) (1).

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development