PQBP1 anticorps (AA 185-265) (HRP)

N° du produit ABIN1411004

L’anticorps Lapin Polyclonal anti-PQBP1 a été validé pour WB, ELISA, IHC (p) et IHC (fro). Il convient pour détecter PQBP1 dans des échantillons de Humain.

Aperçu rapide pour PQBP1 anticorps (AA 185-265) (HRP) (ABIN1411004)

Antigène: PQBP1 (Polyglutamine Binding Protein 1 (PQBP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PQBP1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PQBP1 anticorps (HRP)

Épitope: AA 185-265

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PQBP1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PQBP1

Antigène: PQBP1 (Polyglutamine Binding Protein 1 (PQBP1))

Autre désignation: PQBP1

Sujet:

Synonyms: 38 kDa nuclear protein containing a WW domain, Mental retardation, X linked 55, MRX55, MRXS3, MRXS8, Npw38, Nuclear protein containing WW domain 38 kD, Polyglutamine binding protein 1, Polyglutamine tract binding protein 1, Polyglutamine tract-binding protein 1, Polyglutamine-binding protein 1, PQBP 1, PQBP-1, PQBP1, PQBP1_HUMAN, RENS1, SHS, Sutherland Haan X linked mental retardation syndrome.

Background: Polyglutamine(Q) tract binding protein-1 (PQBP-1) is a transcription repressor that associates with polyglutamine tract-containing transcription regulators and causative genes for neurodegenerative disorders. Hepta- and di-amino acid repeat sequences rich in polar residues are essential for PQBP-1 to interact with polyglutamine tract-containing proteins (i.e. huntingtin, androgen receptor and Brain-2). PQBP-1 contains a WWP/WW domain that binds proline-rich motifs and a C2 domain that can influence Ca2+-dependent phospholipid signaling. PQBP-1 localizes to the nucleus and is present in neurons throughout the brain, with abundant levels in hippocampus, cerebellar cortex and olfactory bulb. The human PQBP-1 gene maps to chromosome Xp11.23.

Pathways: Ribonucleoprotein Complex Subunit Organization