NME4 anticorps (AA 21-120) (Cy3)

N° du produit ABIN1411893

Cet anticorps anti-NME4 est un anticorps Lapin Polyclonal détectant NME4 dans WB, IF (cc) et IF (p). Adapté pour Souris.

Aperçu rapide pour NME4 anticorps (AA 21-120) (Cy3) (ABIN1411893)

Antigène: NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4 (NME4))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NME4 est conjugé à/à la Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-NME4 anticorps (Cy3)

Épitope: AA 21-120

Réactivité croisée: Souris

Homologie: Human,Rat,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NME4/nm23-H4

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NME4

Antigène: NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4 (NME4))

Autre désignation: NME4/nm23-H4

Sujet:

Synonyms: mitochondrial, NDK, NDKM_HUMAN, NDP kinase, NDP kinase, mitochondrial, NDPKD, nm23 H4, nm23-H4, NM23D, Nm23M4, NME4, Non metastatic cells 4 protein expressed in, Nucleoside diphosphate kinase D, Nucleoside diphosphate kinase, mitochondrial.

Background: The nm23 gene (Metastasis inhibition factor nm23), a potential suppressor of metastasis, is expressed at a much lower level in highly metastatic cells than in cells with lower metastatic potential. Based on sequence analysis, nm23, also designated nucleoside diphosphate kinase A (NDK A) or Tumor metastatic process-associated protein, appears to be highly related to nucleotide diphosphate kinases (NDP). NDP kinases A and B are identical to two isotypes of human nm23 homologs, nm23-H1 and nm23-H2, respectively. nm23-H2 is also identical in sequence to PuF, a transcription factor that binds to nuclease-hypersensitive elements at positions 142 to 115 of the human c-Myc promoter. nm23-H3 and nm23-H4 are important for the synthesis of nucleoside triphosphates and may play a role in apoptosis induction and hematopoiesis. nm23-H4 localizes to the mitochondrial intermembrane space and is widely expressed, with higher levels detected in prostate, heart, liver, small intestine, and skeletal muscle tissues. Low amounts of nm23-H4 are observed in the brain and in blood leukocytes.

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process