SLC5A3 anticorps (AA 251-350) (Cy3)

N° du produit ABIN1412187

Cet anticorps anti-SLC5A3 est un anticorps Lapin Polyclonal détectant SLC5A3 dans IF (cc) et IF (p). Adapté pour Humain.

Aperçu rapide pour SLC5A3 anticorps (AA 251-350) (Cy3) (ABIN1412187)

Antigène: SLC5A3 (Solute Carrier Family 5 Member 3 (SLC5A3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC5A3 est conjugé à/à la Cy3

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-SLC5A3 anticorps (Cy3)

Épitope: AA 251-350

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SLC5A3/SMIT

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur SLC5A3

Antigène: SLC5A3 (Solute Carrier Family 5 Member 3 (SLC5A3))

Autre désignation: SLC5A3/SMIT

Sujet:

Synonyms: Na+/myo inositol cotransporter, Na+/myo-inositol cotransporter, SC5A3_HUMAN, SLC5A3, SMIT, SMIT2, sodium/myo inositol cotransporter 1, Sodium/myo inositol cotransporter, Sodium/myo-inositol cotransporter, solute carrier family 5 inositol transporters, member 3, Solute carrier family 5 member 3.

Background: Myo-inositol is involved in many important aspects of cellular regulation including membrane structure, signal transduction and osmoregulation. It is taken up into cells by the sodium/myo-inositol cotransporter (SMIT). SMIT activity maintains intracellular concentrations of myo-inositol, it is upregulated in response to hypertonic stress. The human SMIT protein is encoded by the SLC5A3 gene, which maps to chromosome 21q22.12. It is expressed in many human tissues, such as brain, kidney and placenta. Specifically, SMIT is abundantly expressed throughout the whole brain and spinal cord in fetal rat, but is downregulated in adult rat brain with the exception of the choroid plexus, where SMIT expression remains high. In kidney, SMIT localizes to the baso-lateral membranes of the thick ascending limb of Henle (TAL) and the inner medullary collecting duct (IMCD). Impaired SMIT activity is implicated in the pathogenesis of diabetes and Down syndrome.

Pathways: Inositol Metabolic Process