SLITRK2 anticorps (AA 311-410) (Cy7)

N° du produit ABIN1412196

Cet anticorps anti-SLITRK2 est un anticorps Lapin Polyclonal détectant SLITRK2 dans WB, IF (cc) et IF (p). Adapté pour Humain.

Aperçu rapide pour SLITRK2 anticorps (AA 311-410) (Cy7) (ABIN1412196)

Antigène: SLITRK2 (SLIT and NTRK-Like Family, Member 2 (SLITRK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLITRK2 est conjugé à/à la Cy7

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-SLITRK2 anticorps (Cy7)

Épitope: AA 311-410

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SLITRK2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur SLITRK2

Antigène: SLITRK2 (SLIT and NTRK-Like Family, Member 2 (SLITRK2))

Autre désignation: SLITRK2

Sujet:

Synonyms: CXorf2, KIAA1854, SLIK2_HUMAN, SLIT and NTRK like protein 2, SLIT and NTRK-like protein 2, SLITL1, SLITRK 2, Slitrk2.

Background: SLITRK family proteins are integral membrane proteins that have a C-terminal domain that is partially similar to TRK neurotrophin receptor proteins and two leucine-rich repeat (LRR) domains that are similar to those of SLIT proteins. SLITRK2 (SLIT and NTRK-like protein 2) is a 845 amino acid single-pass type I membrane protein that contains 14 LRR (leucine-rich) repeats and is expressed in neural tissues, with highest levels found in adult cerebral cortex. Overexpression of SLITRK2 leads to inhibition of unipolar neurites in cultured cells, suggesting that it suppresses neurite outgrowth. Inhibitory activity of SLITRK2 is localized to its C-terminal intracellular domain and without this region the protein induces neurite outgrowth. Variants in the gene encoding SLITRK2 may contribute to the development of bipolar disorder, autism spectrum disorder and schizophrenia. There are two isoforms of SLITRK2 that are produced as a result of alternative splicing events.