CACNB4 anticorps (AA 301-400) (Cy5.5)

N° du produit ABIN1412363

L’anticorps anti-CACNB4 Polyclonal Lapin est utilisé pour la détection de CACNB4 dans des échantillons de Humain. Il a été validé pour WB, IF (cc) et IF (p).

Aperçu rapide pour CACNB4 anticorps (AA 301-400) (Cy5.5) (ABIN1412363)

Antigène: CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CACNB4 est conjugé à/à la Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-CACNB4 anticorps (Cy5.5)

Épitope: AA 301-400

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CACNB4/L-type Ca++ CP beta 4

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur CACNB4

Antigène: CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))

Autre désignation: CACNB4/L-type Ca++ CP_4

Sujet:

Synonyms: CAB4, CACB4_HUMAN, Cacnb4, CACNLB4, Calcium channel voltage dependent beta 4 subunit, Calcium channel voltage dependent subunit beta 4, Calcium channel voltage-dependent subunit beta 4, Dihydropyridine sensitive L type calcium channel beta 4 subunit, EA5, EIG9, EJM, EJM4, Voltage-dependent L-type calcium channel subunit beta-4.

Background: Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an Alpha1 subunit, a Beta subunit, a Beta subunit and an Alpha2 Gamma subunit. The Beta subunit is encoded by four genes, designated Beta1-Beta 4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the Beta subunit. L-type Ca++ CP Beta 4, also known as CACNB4 (Calcium channel voltage-dependent subunit beta 4), CACNLB4 or CAB4, is a 484 amino acid protein that contains one SH3 domain and is expressed in ovary, brain and smooth muscle. Functioning as one of the four components of the Beta subunit, L-type Ca++ CP Beta 4 increases the peak calcium current in voltage-dependent calcium channels, thereby shifting the voltage dependencies of activation and inactivation and controlling G protein inhibition and Beta membrane targeting. Two isoforms of L-type Ca++ CP Beta4 exist due to alternative splicing events.

Pathways: cAMP Metabolic Process, Skeletal Muscle Fiber Development