HUNK anticorps (AA 71-115) (HRP)

N° du produit ABIN1412408

L’anticorps anti-HUNK Polyclonal Lapin est utilisé pour la détection de HUNK dans des échantillons de Humain. Il a été validé pour WB, ELISA, IHC (p) et IHC (fro).

Aperçu rapide pour HUNK anticorps (AA 71-115) (HRP) (ABIN1412408)

Antigène: HUNK (Hormonally Up-Regulated Neu-Associated Kinase (HUNK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HUNK est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-HUNK anticorps (HRP)

Épitope: AA 71-115

Homologie: Human,Mouse,Rat,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Serine/threonine-protein kinase MAK-V

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HUNK

Antigène: HUNK (Hormonally Up-Regulated Neu-Associated Kinase (HUNK))

Autre désignation: Serine/threonine-protein kinase MAK-V

Sujet:

Synonyms: B19, Hormonally up-regulated neu tumor-associated kinase, Hormonally upregulated neu associated, Hormonally upregulated neu associated kinase, Hormonally upregulated neu tumor associated kinase, HUNK, HUNK_HUMAN, MAKV, Serine/threonine-protein kinase MAK-V.

Background: The HUNK (hormonally upregulated Neu-associated kinase) protein, also designated MAK-V in mouse, has been identified as a novel SNF1-related serine/threonine kinase. The human HUNK gene localizes to chromosome 21q22 and encodes a protein with nucleocytoplasmic distribution and localizes to the centrosome. Overexpression of the HUNK protein associates with approximately 50 % of breast carcinomas, and may provide diagnostic-prognostic value as a molecular marker. Serine/threonine-protein kinase SNF1-like kinase 2 (SIK) phosphorylates Ser-794 of IRS1 in insulin-stimulated adipocytes, which may modulate the efficiency of insulin signal transduction. SIK is activated by phosphorylation on Thr-175 by STK11 in complex with STE20-related adapter- and CAB39.