RUNX1 anticorps (pSer249) (Cy5)
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- Antigène Voir toutes RUNX1 Anticorps
- RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
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Épitope
- pSer249
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RUNX1 est conjugé à/à la Cy5
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Souris
- Homologie
- Human,Rat,Dog,Cow,Pig,Rabbit,Guinea Pig
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic phosphopeptide derived from human RUNX1 around the phosphorylation site of Ser249 [QP(p-S)PP]
- Isotype
- IgG
- Top Product
- Discover our top product RUNX1 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- RUNX1 (Runt-Related Transcription Factor 1 (RUNX1))
- Autre désignation
- RUNX1 (RUNX1 Produits)
- Synonymes
- anticorps RUNX1, anticorps runx1, anticorps AI462102, anticorps AML1, anticorps Cbfa2, anticorps Pebp2a2, anticorps Pebpa2b, anticorps AML1-EVI-1, anticorps AMLCR1, anticorps CBFA2, anticorps EVI-1, anticorps PEBP2aB, anticorps runxa, anticorps Runx-1, anticorps XAML, anticorps Xaml1, anticorps aml, anticorps aml-1, anticorps aml1, anticorps aml1-evi-1, anticorps amlcr1, anticorps cbfa2, anticorps evi-1, anticorps pebp2ab, anticorps Aml1, anticorps uncharacterized LOC473981, anticorps runt-related transcription factor, anticorps runt related transcription factor 1, anticorps runt-related transcription factor 1, anticorps runt related transcription factor 1 L homeolog, anticorps LOC473981, anticorps runt, anticorps Runx1, anticorps RUNX1, anticorps runx1, anticorps runx1.L
- Sujet
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Synonyms: RUNX1 Ser249, p-RUNX1 Ser249, RUNX1 phospho S249, RUNX1 phospho Ser249, Acute myeloid leukemia 1, Acute myeloid leukemia 1 protein, alpha subunit core binding factor, AML 1, AML1 EVI 1, AML1, Aml1 oncogene, AMLCR 1, AMLCR1, CBFA 2, CBFA2, Core binding factor alpha 2 subunit, Core binding factor runt domain alpha subunit 2, EVI 1, EVI1, HGNC, Oncogene AML 1, PEA2 alpha, PEBP2 alpha B, PEBP2A2, PEBP2aB, Polyomavirus enhancer binding protein 2 alpha B subunit, Run1, Runt related transcription factor 1, RUNX 1, SL3 3 enhancer factor 1 alpha B subunit, SL3/AKV core binding factor alpha B subunit, RUNX1_HUMAN.
Background: AML1/Runx1 binds DNA as a monomer and through the Runt domain. DNA binding is increased by heterodimerization with CBFB. Isoform AML1L can neither bind DNA nor heterodimerize and interferes with the transactivation activity of AML1/Runx1. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T cell receptor enhancers, LCK, IL3 and GMCSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. AML1/Runx1 is expressed in a wide variety of tissues and is expressed at the highest levels in thymus, bone marrow and peripheral blood. Defects in AML1/Runx1 are the cause of familial platelet disorder with associated myeloid malignancy, an autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
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