NSG1 anticorps (AA 1-100) (HRP)

N° du produit ABIN1415878

Cet anticorps Lapin Polyclonal détecte spécifiquement NSG1 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Souris et Singe.

Aperçu rapide pour NSG1 anticorps (AA 1-100) (HRP) (ABIN1415878)

Antigène: NSG1 (D4S234E) (Neuron-Specific Protein Family Member 1 (D4S234E))

Reactivité: Souris, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NSG1 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-NSG1 anticorps (HRP)

Épitope: AA 1-100

Réactivité croisée: Singe, Souris

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NEEP21

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur NSG1

Antigène: NSG1 (D4S234E) (Neuron-Specific Protein Family Member 1 (D4S234E))

Autre désignation: NEEP21

Sujet:

Synonyms: neuron-enriched endosomal 21 kDa protein, NSG1_HUMAN.

Background: NEEP21, also known as Brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (neurotensin receptor 2).