RPE65 anticorps (HRP)

N° du produit ABIN1421362

Cet anticorps Lapin Polyclonal détecte spécifiquement RPE65 dans WB et IHC (p). Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour RPE65 anticorps (HRP) (ABIN1421362)

Antigène: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPE65 est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-RPE65 anticorps (HRP)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RPE65

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur RPE65

Antigène: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Autre désignation: RPE65

Sujet:

Synonyms: All-trans-retinyl-palmitate hydrolase, LCA 2, LCA2, Leber congenital amaurosis, mRPE 65, mRPE65, p63, rd 12, rd12, Retinal pigment epithelium specic 61 kDa protein, Retinal pigment epithelium specic 65 kDa protein, Retinal pigment epithelium specic protein, Retinal pigment epithelium specic protein 65 kDa, Retinal pigment epithelium-specic 65 kDa protein, Retinitis pigmentosa 20, Retinoid isomerohydrolase, RP 20, RP20, RPE 65, RPE65, RPE65_HUMAN, sRPE 65, sRPE65.

Background: The retinal pigment epithelium (RPE) is a monolayer simple epithelium in proximity to the outer surface of the retinal photoreceptor cells. Retinal pigment epithelium-specific protein (RPE65) is a 65 kDa protein belonging to the _-carotene dioxygenase family. This protein is important in 11-cis retinal production as well as in visual pigment regeneration. RPE65 is attached to the membrane by a lipid anchor when palmitoylated (membrane form) and soluble when unpalmitoylated. The soluble form of the protein binds vitamin A. Defects in RPE65 causes autosomal dominant retinitis pigmentosa and/or Leber congenital amaurosis type 2.