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MIS18 Binding Protein 1 (MIS18BP1) anticorps (Cy3)

MIS18BP1 Reactivité: Humain, Souris, Rat WB, IF (p) Hôte: Lapin Polyclonal Cy3
N° du produit ABIN1421531
  • Antigène Voir toutes MIS18 Binding Protein 1 (MIS18BP1) Anticorps
    MIS18 Binding Protein 1 (MIS18BP1)
    Reactivité
    • 18
    • 14
    • 14
    • 1
    Humain, Souris, Rat
    Hôte
    • 16
    • 2
    Lapin
    Clonalité
    • 18
    Polyclonal
    Conjugué
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cy3
    Application
    • 18
    • 12
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human KNL2/C14orf106
    Isotype
    IgG
    Top Product
    Discover our top product MIS18BP1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    MIS18 Binding Protein 1 (MIS18BP1)
    Autre désignation
    C14orf106 (MIS18BP1 Produits)
    Synonymes
    anticorps C14orf106, anticorps HSA242977, anticorps KNL2, anticorps M18BP1, anticorps 6720403H11, anticorps C79407, anticorps Knl2, anticorps mKIAA1903, anticorps MIS18 binding protein 1, anticorps MIS18BP1, anticorps Mis18bp1
    Sujet

    Synonyms: Chromosome 14 open reading frame 106, HsKNL-2, KIAA1903, Kinetochore-associated protein KNL-2 homolog, M18BP1, Mis18-binding protein 1, MIS18BP1, P243, Putative protein p243 which interacts with transcription factor Sp1, Uncharacterized potential DNA binding protein C14orf106, M18BP_HUMAN.

    Background: C14orf106 is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It interacts with SP1. There are two isoforms.Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5 % of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14,19) translocations found in a variety of B cell malignancies. The C14orf106 gene product has been provisionally designated C14orf106 pending further characterization.

    Pathways
    Chromatin Binding
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