MIS18 Binding Protein 1 (MIS18BP1) anticorps (Cy5)

N° du produit ABIN1421532

Cet anticorps anti- est un anticorps Lapin Polyclonal détectant dans WB et IF (p). Adapté pour Humain, Souris et Rat.

Aperçu rapide pour MIS18 Binding Protein 1 (MIS18BP1) anticorps (Cy5) (ABIN1421532)

Antigène: MIS18 Binding Protein 1 (MIS18BP1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cy5

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human KNL2/C14orf106

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détail du antigène

Antigène: MIS18 Binding Protein 1 (MIS18BP1)

Autre désignation: C14orf106

Sujet:

Synonyms: Chromosome 14 open reading frame 106, HsKNL-2, KIAA1903, Kinetochore-associated protein KNL-2 homolog, M18BP1, Mis18-binding protein 1, MIS18BP1, P243, Putative protein p243 which interacts with transcription factor Sp1, Uncharacterized potential DNA binding protein C14orf106, M18BP_HUMAN.

Background: C14orf106 is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. It interacts with SP1. There are two isoforms.Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5 % of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder ?-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14,19) translocations found in a variety of B cell malignancies. The C14orf106 gene product has been provisionally designated C14orf106 pending further characterization.

Pathways: Chromatin Binding