MYBPC3 anticorps (HRP)

N° du produit ABIN1423006

Cet anticorps Lapin Polyclonal détecte spécifiquement MYBPC3 dans WB et IHC (p). Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour MYBPC3 anticorps (HRP) (ABIN1423006)

Antigène: MYBPC3 (Myosin Binding Protein C, Cardiac (MYBPC3))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYBPC3 est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-MYBPC3 anticorps (HRP)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MYBPC3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur MYBPC3

Antigène: MYBPC3 (Myosin Binding Protein C, Cardiac (MYBPC3))

Autre désignation: MYBPC3

Sujet:

Synonyms: C protein cardiac muscle isoform, cardiac muscle isoform, cardiac-type, C-protein, Cardiac MyBP C, Cardiac MyBP-C, Cardiac myosin binding protein C, MYBP C, MYBPC, MYBPC3, Myosin binding protein C cardiac, Myosin binding protein C cardiac-type, Myosin-binding protein C, MYPC3_HUMAN.

Background: MYBPC3 encodes the cardiac isoform of the thick-filament myosin-binding protein C. It is found in the crossbridge-bearing zone (C region) of A bands in vertebrate striated muscle. Regulatory phosphorylation of MYBPC3 by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. MYBPC3 binds F-Actin, MHC and native thin filaments, and modifies the activity of Actin-activated myosin ATPase. Mutations in the MYBPC3 gene lead mainly to truncation of the protein, which results in one cause of familial hypertrophic cardiomyopathy type 4 (CMH4), a heart disorder characterized by ventricular hypertrophy, which often involves the interventricular septum and is usually asymmetric. The MYBPC3 gene maps to chromosome 11p11.2.

ID gène: 4607