CNG Channel beta 1/truncated GARP anticorps (PE)

N° du produit ABIN1425960

Cet anticorps anti- est un anticorps Lapin Polyclonal détectant dans . Adapté pour Humain, Souris et Rat.

Aperçu rapide pour CNG Channel beta 1/truncated GARP anticorps (PE) (ABIN1425960)

Antigène: CNG Channel beta 1/truncated GARP

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: PE

Application: Veuillez nous consulter SVP

Détail du produit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human truncated GARP

Isotype: IgG

Information d'application

Commentaires:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at 4°C

Date de péremption: 12 months

Détail du antigène

Antigène: CNG Channel beta 1/truncated GARP

Sujet:

Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties, it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Subcellular location: Extracellular

Synonyms: CNCG 4, CNCG2, CNCG3L, CNCG4, CNG 4, CNG channel 4, CNG channel beta 1, CNG4, CNGB 1, CNGB1, CNGB1B, Cyclic nucleotide gated cation channel 4, Cyclic nucleotide gated cation channel, Cyclic nucleotide gated cation channel beta 1, Cyclic nucleotide gated cation channel gamma, Cyclic nucleotide gated cation channel modulatory subunit, Cyclic nucleotide gated channel photoreceptor cGMP gated 3 gamma like, Cyclic nucleotide gated channel beta 1, GAR1, GARP, GARP2, Glutamic acid rich protein, RCNC2, RCNCb, RCNCbeta, RP45, 240 kDa protein of rod photoreceptor CNG channel, cGMP gated cation channel beta subunit, Truncated glutamic acid rich protein, Truncated rod photoreceptor cGMP gated channel beta subunit, Truncated rod photoreceptor cGMP-gated channel beta-subunit, CNGB1_HUMAN.