UNC5A anticorps (PE)

N° du produit ABIN1426760

L’anticorps Lapin Polyclonal anti-UNC5A a été validé pour FACS. Il convient pour détecter UNC5A dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour UNC5A anticorps (PE) (ABIN1426760)

Antigène: UNC5A (Unc-5 Homolog A (UNC5A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNC5A est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-UNC5A anticorps (PE)

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Unc5a

Isotype: IgG

Information d'application

Indications d'application: FCM: 1:20-100
Optimal working dilution should be determined by the investigator.

Commentaires:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at 4 °C

Date de péremption: 12 months

Détails sur UNC5A

Antigène: UNC5A (Unc-5 Homolog A (UNC5A))

Autre désignation: Unc5a/Unc5h1

Sujet:

The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is downregulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung and kidney cancers. UNC5H1, also known as UNC5HA (unc-5 homolog A), is a member of the UNC5H family of proteins and is localized to the cell membrane. Three isoforms of UNC5H1 exist due to alternative splicing events.

Subcellular location: Extracellular

Synonyms: Netrin receptor UNC 5A, Netrin receptor UNC5A, Netrin receptor Unc5h1, Protein unc-5 homolog 1, Protein unc-5 homolog A, Unc 5 homolog 1, Unc 5 homolog A, Unc 5a, Unc5 a, Unc5 homolog 1, Unc5 homolog A, Unc5a, UNC5A_HUMAN, Unc5h1, FLJ16449, KIAA1976.