C18orf1 anticorps (PE)

N° du produit ABIN1436977

Cet anticorps Lapin Polyclonal détecte spécifiquement C18orf1 dans WB. Il présente une réactivité envers Humain, Souris, Rat et Boeuf (Vache).

Aperçu rapide pour C18orf1 anticorps (PE) (ABIN1436977)

Antigène: C18orf1 (Chromosome 18 Open Reading Frame 1 (C18orf1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp C18orf1 est conjugé à/à la PE

Application: Western Blotting (WB)

Détail du produit anti-C18orf1 anticorps (PE)

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human C18orf1

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur C18orf1

Antigène: C18orf1 (Chromosome 18 Open Reading Frame 1 (C18orf1))

Autre désignation: C18orf1

Sujet:

Synonyms: C18orf1, Low-density lipoprotein receptor class A domain-containing protein 4, LDLRAD4

Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

Poids moléculaire: 34kDa

ID gène: 753

UniProt: O15165