ES1 Protein Homolog (AA 1-281), (full length), (N-Term) anticorps

N° du produit ABIN1449175

Cet anticorps Rat Monoclonal détecte spécifiquement ES1 Protein Homolog dans IF, IHC (p), IP et WB. Il présente une réactivité avec des échantillons de Rat.

Aperçu rapide pour ES1 Protein Homolog (AA 1-281), (full length), (N-Term) anticorps (ABIN1449175)

Antigène: ES1 Protein Homolog

Reactivité: Rat

Hôte: Rat

Clonalité: Monoclonal

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)

Clone: NM1

Détail du produit

Épitope: AA 1-281, full length, N-Term

Specificité: This antibody reacts with rat HES1.

Purification: Protein G agarose

Immunogène: Full-length rat HES1 (1-281 aa)

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détail du antigène

Antigène: ES1 Protein Homolog

Sujet: Two transcription factors with a helix-loop-helix motif, human achaete-scute homologue-1 (hASH1) and hairy/enhancer of split homologue-1 (HES1), are essential for proper neuronal development. hASH1 is constitutively expressed in the most virulent human lung cancer, small cell lung cancer (SCLC), which exhibits neuroendocrine (NE) features. Moreover, hASH1 is essential for development of normal pulmonary NE cells that resemble SCLC. HES1 acts to transcriptionally repress hASH1 expression. The repressive effect of HES1 is mediated by binding of the protein to a class C site in the hASH1 promoter. HES1 also plays a role in mid- and hindbrain development, and in Notch signaling in thymocytes.Synonyms: C21orf33, HES1, KNPI, Protein GT335, Protein KNP-I

ID gène: 294326

NCBI Accession: NP_001004225

UniProt: P56571