CD300a anticorps

N° du produit ABIN1449208

Cet anticorps Rat Monoclonal détecte spécifiquement CD300a dans FACS. Il présente une réactivité envers Souris.

Aperçu rapide pour CD300a anticorps (ABIN1449208)

Antigène: CD300a (CD300A)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD300a est non-conjugé

Application: Flow Cytometry (FACS)

Clone: TX40

Détail du produit anti-CD300a anticorps

Specificité: This antibody reacts with mouse CD300a.

Purification: Protein G agarose

Immunogène: Mouse MAIR-I transfected Ba/F3 cells

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur CD300a

Antigène: CD300a (CD300A)

Autre désignation: CD300A / CMRF35H

Sujet: Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Shibuya et al. identified novel paired activated and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domains. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12. MAIR-I is also known as CD300a/ CMRF-35-like Ig-like molecule-8 (CLM-8)/leukocyte mono-Ig-like receptor 1 (LMIR1). MAIR-II is also known as CD300d/LMIR2/CLM-4/dendritic cell-derived Ig-like receptor 1 (DIgR1).Synonyms: CD300 antigen-like family member A, CLM-8, CMRF-35-H9, CMRF35-H, CMRF35-H9, CMRF35-like molecule 8, IRC1/IRC2, IRp60, Inhibitory receptor protein 60, NK inhibitory receptor

ID gène: 217303

NCBI Accession: NP_739564

UniProt: Q6SJQ0

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process