PSME1 anticorps

N° du produit ABIN1449243

Cet anticorps anti-PSME1 Monoclonal Souris (Clone 1G11) (ABIN1449243) détecte spécifiquement PSME1 dans WB, IP et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PSME1 anticorps (ABIN1449243)

Antigène: PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PSME1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1G11

Détail du produit anti-PSME1 anticorps

Specificité: This antibody detects PA28α on Western blotting, Immunoprecipitation and Immunohistochemistry. Species Reactivity on Western Blot: Human: HeLa, Jurkat, Raji, HL-60, A431, U937, HEL. Mouse: L5178Y, NIH/3T3. Rat: Rat-1.Species Reactivity on Western Blot:

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat.

Immunogène: Recombinant Mouse full length PA28alpha

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2, None, 50 % Glycerol

Agent conservateur: Azide free

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur PSME1

Antigène: PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))

Autre désignation: PSME1

Sujet: PA28, also called 11S regulator, was identified as a proteasome activator that strongly increases the maximal velocity of the hydrolytic reaction and decreases the concentration of substrate required for cleavage by purified 20S proteasomes. It is known that major histocompatibility complex (MHC) class I ligands are mainly produced by the proteasome. PA28 also plays an important role in the processing of MHC class I ligands. However, isolated PA28 does not perform enzymatic activity by itself. PA28 is composed of two homologous subunits, PA28α (30 kDa) and PA28ß. These two subunits assemble into a heterohexamer (α3ß3) or a heteroheptomer (α3ß4 or mixture of α3ß4 and α4ß3). The PA28 complex is expressed constitutively in antigen presenting cells, its expression is upregulated by IFN-γIt appears to be involved in the presentation of endogenous antigen by MHC class I molecules.Synonyms: 11S regulator complex subunit alpha, Activator of multicatalytic protease subunit 1, IFI5111, IGUP I-5111, Interferon gamma up-regulated I-5111 protein, PA28a, PA28alpha, PSME-1, Proteasome activator 28 subunit alpha, Proteasome activator complex subunit 1, REG-alpha

ID gène: 5720

NCBI Accession: NP_006254

UniProt: Q06323

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA