SIPA1 anticorps

N° du produit ABIN1449260

Détail du produit anti-SIPA1 anticorps

Antigène: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Reactivité: Souris, Hamster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIPA1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Réactivité croisée (Details): Species reactivity (tested):Mouse (Ba/F3, NIH/3T3, WR19L, MEF), Hamster (CHO). Does not react with Human (HL-60, Jurkat, Raji) or Rat (Rat-1).

Purification: Anion exchange column chromatography

Immunogène: Wister rat splenocyte immunized with the baculoviral expressed recombinant mouse SPA-1

Clone: 2-22-9

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur SIPA1

Antigène: SIPA1 (Signal-Induced Proliferation-Associated 1 (SIPA1))

Autre désignation: SIPA1 / SPA1 (SIPA1 Produits)

Synonymes: anticorps Spa1, anticorps SPA1, anticorps signal-induced proliferation-associated 1, anticorps Signal peptidase I (leader peptidase I), anticorps signal-induced proliferation associated gene 1, anticorps SIPA1, anticorps sipA1, anticorps Sipa1

Sujet: SPA-1 , signal-induced proliferation associated gene 1, encodes a 130 kDa protein (p130 SPA-1 ) with a domain related to Rap1 GTPase activating protein (Rap1GAP) at the N-terminus and to PDZ protein interaction domain followed by a leucine zipper motif at the C-terminus. It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for other small GTPases. p130 SPA-1 was mostly localized at both the plasma membrane and the perinuclear membranous region co-localizing with Rap1 and Rap2. Expression of SPA-1 and rap1GAP genes tended to be segregate in various tissues, lymphoid and hematopoietic tissues expressing abundant SPA-1 transcript without rap1GAP , while those such as brain, kidney and pancreas exhibiting rap1GAP mRNA with little SPA-1 .Synonyms: GTPase-activating protein Spa-1, Signal-induced proliferation-associated protein 1, Sipa-1, Spa-1, p130 SPA-1

ID gène: 10090

UniProt: P46062

Pathways: Response to Water Deprivation