ICAM1 anticorps

N° du produit ABIN1449267

Cet anticorps anti-ICAM1 Monoclonal Souris (Clone WK1) (ABIN1449267) détecte spécifiquement ICAM1 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ICAM1 anticorps (ABIN1449267)

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ICAM1 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: WK1

Détail du produit anti-ICAM1 anticorps

Purification: Protein A agarose

Immunogène: Human myeloma cell line (RPMI8226)

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliqouts) at -20 °C.

Détails sur ICAM1

Antigène: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Autre désignation: CD54 / ICAM1

Sujet: Intercellular adhesion molecules (ICAMs) are type I transmem brane glycoproteins, which contain 2-9 immunoglobulin-like C2-type domains, and bind to lymphocyte function- associated antigen-1 (LFA-1, also known as a L/ ß 2 or CD11a/CD18). ICAM-1 (CD54) binds to not only LFA-1 but also CD11b/CD18 (Mac-1) and CD11c/CD18. ICAM-1 is also the major receptor for human rhinovirus. ICAM-1 and LFA-1 are involved in the formation of the adhesion ring junction at the immunologic synapse between T cells and antigen presenting cells. ICAM-1 is expressed at low levels on diverse cell types, and is readily induced by activation with proinflammatory cytokines such as IL-1, TNF, IFN- γ , and GM-CSF. ICAM-1 plays a role in both adhesion and extravasation of leukocytes to endothelium during inflammation. Soluble forms of ICAM-1 (sICAM-1) have been detected in a variety of body fluids and correlated with the intensity of the clinical condition of inflammatory and immune disorders. Several studies have provided evidence that sICAM-1 can bind to cell surface ß 2 integrins (CD18), causing reduced adherence of leukocytes to endothelial cells and the accompanying intracellular signaling responses.Synonyms: ICAM-1, Intercellular adhesion molecule 1, Major Group Rhinovirus Receptor

ID gène: 9606

UniProt: P05362

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling