CD5 anticorps (APC)

N° du produit ABIN1449304

Cet anticorps Souris Monoclonal détecte spécifiquement CD5 dans FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour CD5 anticorps (APC) (ABIN1449304)

Antigène: CD5

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD5 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Clone: L17F12

Détail du produit anti-CD5 anticorps (APC)

Réactivité croisée (Details): Species reactivity (tested):Human

Immunogène: Human acute lymphoblastic leukemia (ALL) T cells

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS, 15 mM sodium azide, 0.2 % (w/v) high-grade protease free Bovine Serum Albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE! This products is photosensitive and should be protected from light.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Détails sur CD5

Antigène: CD5

Autre désignation: CD5

Sujet: CD5 antigen (T1, 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies. Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL, Hairy cell leukemia, etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis, etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5

ID gène: 921

NCBI Accession: NP_055022

UniProt: P06127