ARNTL2
Reactivité: Humain
WB, IF (cc), IF (p)
Hôte: Lapin
Polyclonal
AbBy Fluor® 594
Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Reconstitution
Add 50 μL of distilled water to a final concentration of 1 mg/mL.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store lyophilized at 2-8 °C for one month or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
ARNTL2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription. Also, in umbilical vein endothelial cells, ARNTL2 activates SERPINE1 through E-box sites. This transactivation is inhibited by PER2 and CRY1. It is xxpressed in fetal brain and highly expressed in brain and placenta. Lower levels are found in heart, liver, thymus, kidney and lung. It is located to endothelial cells and neuronal cells of the suprachiasmatic nucleus (SCN) and also detected in endothelial cells of the heart, lung and kidney. In the brain, it is specifically expressed in the thalamus, hippocampus and amygdala.Synonyms: Aryl hydrocarbon receptor nuclear translocator-like protein 2, BHLHE6, Basic-helix-loop-helix-PAS protein MOP9, Brain and muscle ARNT-like 2, CLIF, CYCLE-like factor, Class E basic helix-loop-helix protein 6, MOP9, Member of PAS protein 9, PAS domain-containing protein 9, PASD9, bHLHe6