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AKTIP anticorps (Middle Region)

AKTIP Reactivité: Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Poulet, Xenopus laevis WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN1449900
  • Antigène Voir toutes AKTIP Anticorps
    AKTIP (AKT Interacting Protein (AKTIP))
    Épitope
    • 30
    • 11
    • 8
    • 8
    • 6
    • 1
    • 1
    Middle Region
    Reactivité
    • 34
    • 30
    • 23
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Poulet, Xenopus laevis
    Hôte
    • 58
    • 6
    Lapin
    Clonalité
    • 61
    • 3
    Polyclonal
    Conjugué
    • 16
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp AKTIP est non-conjugé
    Application
    • 53
    • 26
    • 26
    • 26
    • 6
    • 6
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Séquence
    NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat, Chicken, Dog, African clawed frog, ZebrafishSpecies reactivity (tested):Human
    Purification
    Purified using peptide immunoaffinity column
    Immunogène
    Synthetic peptide directed towards the middle region of human AKTIP
    Top Product
    Discover our top product AKTIP Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Reconstitution
    Add 50 μL of distilled water to a final concentration of 1 mg/mL.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
  • Antigène
    AKTIP (AKT Interacting Protein (AKTIP))
    Autre désignation
    AKTIP / FTS (AKTIP Produits)
    Synonymes
    anticorps FT1, anticorps FTS, anticorps cb798, anticorps fts, anticorps zgc:77699, anticorps fts-A, anticorps aktip, anticorps fts-B, anticorps MGC133931, anticorps AL023020, anticorps Fif, anticorps Ft, anticorps Ft1, anticorps Fts, anticorps AKT interacting protein, anticorps akt interacting protein, anticorps AKT interacting protein L homeolog, anticorps AKT interacting protein S homeolog, anticorps thymoma viral proto-oncogene 1 interacting protein, anticorps AKTIP, anticorps aktip, anticorps aktip.L, anticorps aktip.S, anticorps Aktip
    Sujet
    AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.Synonyms: AKT-interacting protein, FT1, Fused toes protein homolog
    ID gène
    64400
    NCBI Accession
    NP_001012398
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