TTBK2 anticorps (C-Term)

N° du produit ABIN1449960

Détail du produit anti-TTBK2 anticorps

Antigène: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TTBK2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid synthetic peptide near the carboxy terminus of Human TTBK2

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur TTBK2

Antigène: TTBK2 (tau Tubulin Kinase 2 (TTBK2))

Autre désignation: TTBK2 (TTBK2 Produits)

Synonymes: anticorps ttbk, anticorps MGC146331, anticorps 2610507N02Rik, anticorps AI326283, anticorps B930008N24Rik, anticorps TTK, anticorps Ttbk, anticorps Ttbk1, anticorps mKIAA0847, anticorps SCA11, anticorps TTBK, anticorps tau tubulin kinase 2, anticorps TTBK2, anticorps ttbk2, anticorps Ttbk2

Sujet: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.Synonyms: KIAA0847, Tau-tubulin kinase 2

ID gène: 146057