CARD14 anticorps (C-Term)

N° du produit ABIN1449966

Cet anticorps anti-CARD14 est un anticorps Lapin Polyclonal détectant CARD14 dans IHC (p) et EIA. Adapté pour Humain.

Aperçu rapide pour CARD14 anticorps (C-Term) (ABIN1449966)

Antigène: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CARD14 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-CARD14 anticorps

Épitope: C-Term

Purification: Affinity Chromatography purified via peptide column

Immunogène: 14 amino acid synthetic peptide near the carboxy terminus of Human CARMA2

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CARD14

Antigène: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Autre désignation: CARD14 / CARMA2

Sujet: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein activated NF-kB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-kB activation and endoplasmic reticulum stress-induced cell death.Synonyms: CARD-containing MAGUK protein 2, Caspase recruitment domain-containing protein 14

ID gène: 79092

NCBI Accession: NP_077015