SCUBE3 anticorps (Middle Region)

N° du produit ABIN1449994

Cet anticorps Lapin Polyclonal détecte spécifiquement SCUBE3 dans WB, IF et EIA. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour SCUBE3 anticorps (Middle Region) (ABIN1449994)

Antigène: SCUBE3 (Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SCUBE3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-SCUBE3 anticorps

Épitope: Middle Region

Purification: Affinity chromatography purified via peptide column

Immunogène: A 15 amino acid synthetic peptide near the center of Human SCUBE3

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SCUBE3

Antigène: SCUBE3 (Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3))

Autre désignation: SCUBE3

Sujet: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart. Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth.. SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta1, VEGF, Snail, and Slug.Synonyms: CEGF3, Signal peptide CUB and EGF-like domain-containing protein 3

Poids moléculaire: 109 kDa

ID gène: 222663

NCBI Accession: NP_689966