BCL6 anticorps (Middle Region)

N° du produit ABIN1449999

Détail du produit anti-BCL6 anticorps

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCL6 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of Human BCL6

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BCL6

Antigène: BCL6 (B-Cell CLL/lymphoma 6 (BCL6))

Autre désignation: Bcl-6 (BCL6 Produits)

Synonymes: anticorps bcl5, anticorps laz3, anticorps bcl6a, anticorps znf51, anticorps zbtb27, anticorps MGC132260, anticorps Bcl5, anticorps BCL5, anticorps BCL6A, anticorps LAZ3, anticorps ZBTB27, anticorps ZNF51, anticorps B-cell CLL/lymphoma 6 L homeolog, anticorps B-cell CLL/lymphoma 6, anticorps B cell leukemia/lymphoma 6, anticorps bcl6.L, anticorps bcl6, anticorps BCL6, anticorps Bcl6

Sujet: BCL6 was first identified as a proto-oncogene in diffuse large B cell lymphoma. BCL6, a transcriptional repressor, plays an important role in lymphomagenesis. It binds Stat recognition-like DNA elements and is required for affinity maturation of mature B cells in germinal centers and Th1/Th2 differentiation, a process that critically depends on BCL6-mediated transcriptional repression of p53. BCL6 is a pharmacological target for eradication of leukemia-initiating cells in chronic myeloid leukemia (CML).Synonyms: B-cell lymphoma 6 protein, BCL-5, BCL5, BCL6, LAZ-3, LAZ3, ZBTB27, ZNF51, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51

Poids moléculaire: 78 kDa

ID gène: 604

NCBI Accession: NP_001124317

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus