CENPW anticorps (N-Term)

N° du produit ABIN1450011

Détail du produit anti-CENPW anticorps

Antigène: CENPW (Centromere Protein W (CENPW))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CENPW est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid synthetic peptide near the amino terminus of Human CENPW

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CENPW

Antigène: CENPW (Centromere Protein W (CENPW))

Autre désignation: CENP-W (CENPW Produits)

Synonymes: anticorps C6orf173, anticorps CUG2, anticorps 2610036L11Rik, anticorps Cug2, anticorps CENP-W, anticorps centromere protein W, anticorps CENPW, anticorps Cenpw

Sujet: CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.Synonyms: C6orf173, CENPW, CUG2, Cancer-up-regulated gene 2 protein, Centromere protein W

ID gène: 387103

NCBI Accession: NP_001012525