AFAP anticorps (N-Term)

N° du produit ABIN1450096

Cet anticorps Lapin Polyclonal détecte spécifiquement AFAP dans WB et EIA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour AFAP anticorps (N-Term) (ABIN1450096)

Antigène: AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AFAP est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-AFAP anticorps

Épitope: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogène: AFAP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of Human AFAP1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur AFAP

Antigène: AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))

Autre désignation: AFAP1

Sujet: The actin filament-associated protein AFAP1 (AFAP-110) is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP1 has a fundamental role in actin cytoskeleton arrangement. It contains a carboxyterminal actin-binding domain that directly binds to F-actin and serves as an adaptor protein in the regulation of SRC and PKC signal transduction by several functional domains, including 2 pleckstrin homology (PH) domains, a Src homology 3-binding (SH3-binding) motif, and several SH2-binding motifs. It is overexpressed in prostate carcinoma and contributes to tumor growth by regulating cell-matrix adhesions and migration in the cancer cells. AFAP1 represent a possible therapeutic target for controlling tumorigenesis and metastasis.Synonyms: 110 kDa actin filament-associated protein, AFAP-110, Actin filament-associated protein 1

ID gène: 60312

NCBI Accession: NP_940997